Abstract
A series of aromatic acetic acid compounds were designed and synthesized on the basis of Non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Compounds 5a, 7a, 5h, 7h and 17 could strongly promote insulin-regulated differentiation of 3T3-L1 cells in vitro. They acted as full or partial PPARgamma agonist, or improved insulin resistance through non-PPARgamma pathway.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3T3-L1 Cells
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Cell Differentiation / drug effects
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Cyclooxygenase Inhibitors / chemistry
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Cyclooxygenase Inhibitors / pharmacology
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Diclofenac / chemistry
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Diclofenac / pharmacology*
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Drug Design
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Indomethacin / chemistry
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Indomethacin / pharmacology*
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Insulin / pharmacology
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Insulin Resistance*
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Mice
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PPAR gamma / agonists
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PPAR gamma / metabolism
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Rats
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Cyclooxygenase Inhibitors
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Insulin
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PPAR gamma
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Diclofenac
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Indomethacin